ABSTRACT
BACKGROUND Patients with severe coronavirus disease 2019 (COVID-19) often present with coagulopathies and have high titres of circulating antibodies against viral proteins. OBJECTIVES Herein, we evaluated the association between D-dimer and circulating immunoglobulin levels against viral proteins in patients at different clinical stages of COVID-19. METHODS For this, we performed a cross-sectional study involving patients of the first wave of COVID-19 clinically classified as oligosymptomatic (n = 22), severe (n = 30), cured (n = 27) and non-infected (n = 9). Next, we measured in the plasma samples the total and fraction of immunoglobulins against the nucleoprotein (NP) and the receptor-binding domain (RBD) of the spike proteins by enzyme-linked immunosorbent assay (ELISA) assays. FINDINGS Patients with severe disease had a coagulation disorder with high levels of D-dimer as well as circulating IgG against the NP but not the RBD compared to other groups of patients. In addition, high levels of D-dimer and IgG against the NP and RBD were associated with disease severity among the patients in this study. MAIN CONCLUSIONS Our data suggest that IgG against NP and RBD participates in the worsening of COVID-19. Although the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is partially understood, and more efforts are needed to clarify gaps in the knowledge of this process.
ABSTRACT
A internação por longo período em uma Unidade de Terapia Intensiva Neonatal pode comprometer os laços afetivos entre pais e filhos. Durante a assistência, percebe-se mais frequentemente a presença materna, porém os pais passam por uma ambivalência de sentimentos, sendo esse período transformador marcado principalmente por medo e esperança. O objetivo do estudo foi entender um pouco mais a pessoa paterna em uma Unidade de Terapia Intensiva Neonatal e seus sentimentos. Trata-se de um estudo do tipo bibliográfico, retrospectivo e exploratório com análise sistematizada, em que foram analisados artigos das bases de dados virtuais em saúde no período compreendido entre 2001 e 2013. Ficou evidenciado sobre esse tema, ainda pouco estudado, que, apesar de estar em crescimento o envolvimento paterno em todos os aspectos da família, suas atitudes ainda são tímidas e pouco reveladas, e as falas muito reservadas. Além disso, os profissionais de saúde bem como os pesquisadores valorizam muito o vínculo mãe-bebê e se esquecem da tríade de extrema relevância mãe-pai-bebê.
Long stays in neonatal intensive care units can compromise the affectional bonds between parents and children. Mothers are present more often, but both parents experience ambivalent feelings as this transformation period is marked mainly by fear and hope. The study aimed to better understand fathers in a neonatal intensive care unit and their feelings. This is a retrospective, exploratory study that systematically analyzed articles from indexed virtual health databases published between 2001 and 2013. Although this subject has hardly been studied, it became evident that the father?s involvement in all aspects of the family is growing, but his attitudes are still timid and barely revealed, and his lines are very reserved. Moreover, health professionals and researches greatly value the mother-infant bond and forget the very important mother-father-baby triad.
Subject(s)
Infant, Newborn , Paternity , Infant, Premature , Intensive Care Units, NeonatalABSTRACT
Objetivo: O presente estudo visou a avaliar a qualidade de vida da equipe de enfermagem do pronto-socorro e centro de terapia intensiva em hospitais de Itajubá e Pouso Alegre, Minas Gerais, e correlacionar as variáveis sociodemográficas e de saúde à qualidade de vida. Métodos: O estudo, com 87 colaboradores, foi de abordagem quantitativa e transversal. Instrumentos: caracterização sociodemográfica e de saúde e World Health Organization Quality of Life Assessment-bref. O domínio físico apresentou maior destaque, e o domínio meio ambiente, menor pontuação. Resultados: As variáveis que apresentaram correlação com a qualidade de vida foram renda e estado de saúde. Conclusão: O estudo concluiu que a qualidade de vida é diretamente proporcional ao estado de saúde, visto que quanto melhor o estado de saúde, melhor a qualidade de vida, e que é indiretamente proporcional à renda dos entrevistados.
Objective: The present study aimed to evaluate the quality of life of the nursing staff of the emergency room and intensive care units in hospitals in Itajubá and Pouso Alegre, Minas Gerais and correlate the sociodemographic and health quality of life. Methods: The study was cross-sectional quantitative approach and 87 employees. Instruments: characterization sociodemographic and health and World Health Organization Quality of Life Assessment-bref. The Physical Domain showed greater prominence and Domain Environment with lower scores. Results: The variables that correlated with quality of life were income and health status. Conclusion: The study concluded that quality of life is directly proportional to the health status, seen as better health status and better quality of life which is indirectly proportional to the income of the respondents.